RNA biology; alternative splicing; RNA interference; WT1; VEGF; H-Ras; HER-2; IR; TMPRSS2/ERG; microRNAs

Datum objave: 11.04.2011

Kategorija: Aktualno na Univerzi

University of the West of England, Bristol

Contact Person

LADOMERY, Michael (Dr)
Reader in Biomedical Science and principal investigator, RNA biology group
University of the West of England, Bristol

Telephone: +44-117-3283531
Fax: +44-117-3282904


Project Proposal

Title: RNA biology; alternative splicing; RNA interference; WT1; VEGF; H-Ras; HER-2; IR; TMPRSS2/ERG; microRNAs

Type Details: Dr Michael Ladomery - RNA Biology Group.

I am interested in post-transcriptional processes, with a focus on alternative splicing in development and disease.

Specific projects which I am involved include: the role of the Wilms tumour suppressor gene WT1 in development; alternative splicing of the Vascular Endothelial Growth Factor VEGF; and alternative splicing of ERG and AR and HER2.

I am interested in joining projects focused on 'post-transcriptional processes' with particular emphasis on alternative splicing, mRNA translation and stability regulation, and projects involving microRNAs.

As well as WT1 and VEGF, other genes/proteins I have worked on, and am interested in pursuing include the mRNP and 'P-body' associated proteins: Y-box protein YB-1; RNA helicase p54; and RAP55.

I have also worked in the plant biology field, specifically on the glycine rich RNA binding proteins atGRP7 and atGRP8; and their roles in adapting plants to environmental stress.

My lab can offer: proteomics including DiGE multiplexing and in house MALDI and Q-TOF; real-time PCR; microarrays; tissue culture; RNA interference.

My current projects and research background are listed on my website: (RNA Biology group): http://www.ladomerylab.org


Research Interest: Genetics, cytogenetics; Development biology, teratology, ontogeny, embryology (human); Biochemistry; Urology, nephrology; General Biomedical Sciences

Expiry Date: 2012-03-03

Workprogramme area(s)

(FP7-HEALTH HEALTH-1) Biotechnology, generic tools and medical technologies for human health

(FP7-HEALTH HEALTH-1.1) High-throughput research

(FP7-HEALTH HEALTH-2007-1.2) Detection, diagnosis and monitoring

(FP7-HEALTH HEALTH-2007-1.4) Innovative therapeutic approaches and interventions

(FP7-HEALTH HEALTH-2007-2) Translating research for human health

(FP7-HEALTH HEALTH-2007-2.1) Integrating biological data and processes: large-scale data gathering, systems biology

(FP7-HEALTH HEALTH-2007-2.2.2) Human development and ageing

(FP7-HEALTH HEALTH-2007-2.4) Translational research in other major diseases

(FP7-HEALTH HEALTH-2007-2.4.1) Cancer

(FP7-HEALTH HEALTH-2007-2.4.2) Cardiovascular diseases

(FP7-HEALTH HEALTH-2007-2.4.3) Diabetes and obesity

(FP7-HEALTH HEALTH-2007-2.4.4) Rare diseases

(FP7-HEALTH HEALTH-2007-3.5) Specific international cooperation actions for health system research

(FP7-HEALTH HEALTH-2007-4) Other Actions across the Health Theme

(FP7-ICT ICT-2007.1.2) Service and Software Architectures, Infrastructures and Engineering

(FP7-ICT ICT-2007.1.6) New paradigms and experimental facilities

(FP7-ICT ICT-2007.4) Digital libraries and content

(FP7-ICT ICT-2007.5) Towards sustainable and personalised healthcare

(FP7-ICT ICT-2007.5.3) Virtual physiological human

(FP7-ICT ICT-2007.7.1) ICT and ageing

(FP7-ICT ICT-2007.2) Cognitive systems, interaction, robotics (ICT-2007.2)

(FP7-ICT ICT-2007.2.1) Cognitive Systems, Interaction, Robotics

(FP7-ICT ICT-2007.2.2) Cognitive systems, interaction, robotics (ICT-2007.2.2)

Target Partner

Expertise: An interest in the post-transcriptional field. Generation of minigene constructs to study alternative splicing. In vitro splicing assays. Microarrays representing alternative splicing. RNA interference. MicroRNA analysis. RNA:protein interactions. Access to animal models. Access to tumour specimens.

Organisation Details

University of the West of England, Bristol

Name: University of the West of England, Bristol

Department: Centre for Research in Biomedicine, Faculty of Health and Life Sciences


Address: Coldharbour Lane


Type: Education; Research

Number of Employees: > 500

Keywords: alternative splicing; WT1; VEGF; H-Ras; HER2; zinc finger proteins; P-bodies; microRNAs

Partners already acquired: Partners acquired in previous FP7 bids:

Bar-Ilan University, Israel
Institute Rudjer Boskovic, Croatia
Delft University of Technology, Netherlands
Technische Universitat Dresden, Germany
Applied Spectral Imaging (ASI), Israel
Surface Innovations Ltd, UK
Genovum, Poland
Vratis, Poland
Pyrogenesis-SA, Greece
Progenika Biopharma SA, Spain
OSM-Dan Ltd, Israel

Technological Educational Institute of Athens, Greece
RR & CO Knowledge Centre Ltd, Slovenia
University of Helsinki, Finland
Biomedical Research Foundation of the Academy of Athens, GR.
University of Patras, Greece
Tampere University of Technology, Finland
Technische Universitat Graz, Austria
Turku Centre for Biotechnology, Finland
Teknillinen Korkeakoulu, Finland
Swiss Federal Institute of Technology, Zurich, Switzerland
Wise technologies software devt. Ltd. Slovenia

Dr Montse Bach-Elias (CID-CSIC, Barcelona, Spain)
Dr Stefano Volinia (Universita di Ferrara, Italy)
Dr Marc Rehmsmeier (University of Bielefeld, Germany).
Dr Ana Carmen Martin (BIONOSTRA - SME, Madrid Spain).

RCN: 69726

Quality Validation Date: 2011-03-03

Update Date: 2011-03-09