Model organism research including small molecule screening (using Zebrafish, Chick, Drosophila) in major and rare diseases

Datum objave: 01.06.2011

Kategorija: Aktualno na Univerzi

MRC Centre for Developmental and Biomedical Genetics at the University of Sheffield

Contact Person

SMITH, Susan (Dr.)
Research Translator
MRC Centre for Developmental and Biomedical Genetics at the University of Sheffield

http://cdbg.shef.ac.uk/
Contact
Telephone: +22-222-4673

Collaboration

Project Proposal


Title: Model organism research including small molecule screening (using Zebrafish, Chick, Drosophila) in major and rare diseases

Type Details: he MRC Centre for Developmental and Biomedical Genetics central purpose is to bring together developmental geneticists with clinician scientists, creating a focus of expertise in the generation of animal models of human disease with the aim of stimulating the translation of findings from model systems to the development of novel therapies and clinical practice. The principal strategy of the CDBG is to use genetically tractable model organisms to analyse normal and aberrant cellular behaviour in an in vivo context.

An extensive range of techniques employed in the experimental analysis of Drosophila and zebrafish, including mutagenesis, transgenesis, anti-sense inhibition, cell transplantation, and real time imaging of embryos is well established in the Centre. In addition, a Zebrafish screening facility has also been established within the centre which allows small molecule screening in the whole zebrafish embryo.

With sixteen full members and eight associate members, each heading an independent research laboratory, the cdbg has around 100 postdoctoral research assistants, post graduate students and technical staff. It boasts some of the finest research facilities in the U.K. and attracts annual grant income in excess of L2m.

Core funding for the Centre is provided by the Medical Research Council (MRC) while individual research projects are supported by a number of agencies including the MRC, the BBSRC, The Wellcome Trust, Cancer Research U.K as well as the European Union 6 and 7th framework Programmes.


Programme (Collaboration EU R&D): FP7-COOPERATION, FP7-HEALTH, FP7-NMP, FP7-PEOPLE


Expiry Date: 2012-05-06


Target Partner


Organisation Details

MRC Centre for Developmental and Biomedical Genetics at the University of Sheffield

Name: MRC Centre for Developmental and Biomedical Genetics at the University of Sheffield

Region: YORKSHIRE AND HUMBERSIDE
SOUTH YORKSHIRE

Address: Firth Court
Western Bank
Sheffield, UK

Sheffield   S10 2TN UNITED KINGDOM


Type: Research; Education; Non Commercial

Number of Employees: > 500

Keywords: Non-mammalian model organims;Screening;Major and Rare diseases



RCN: 87044

Quality Validation Date: 2011-05-06

Update Date: 2011-05-12