The UL Infrastructure Programme is important in terms of supporting participation in the ESFRI international infrastructure projects, which UL member institutions carry out via their infrastructure centres: the Faculty of Social Sciences (CESSDA and ESS), the Faculty of Pharmacy (EATRIS), the Faculty of Medicine (ELIXIR and SiMBioN) and the Faculty of Chemistry and Chemical Technology (E-RIHS).

The organisation of national nodes of the ESFRI European infrastructure projects is based on strategic cooperation between partners and the establishment of a system that provides access to information. In addition, it makes it possible to conduct independent research and is based on an open search for partners at companies or in the relevant industries.

Through this, the UL has increased its competitiveness because the role of a national node is also about the promotion of national centres and expertise in Europe, achieving complementarity, seeking synergies for joint participation in international programmes and directing national investment in major research infrastructure.

The CESSDA is an organisational and professional upgrade of the social science data infrastructure. It takes advantage of the possibility of collaboration between national organisations territorially in charge of data management at the European level by integrating work on development projects, implementing standardised solutions to managing data materials and standardising the quality of service provision.

In Slovenia, the ESS project provides high-quality internationally comparable social science data to over 150,000 users around the globe and over 4,500 users in Slovenia.

The ESS-ERIC survey is one of the best social science research infrastructures at the European scale. It provides data sources for research on the social-climate dynamics in a changing Europe. The survey instrument is a questionnaire that measures the attitudes, behaviours and living conditions of the European population, using over a hundred indicators and ensuring full data comparability for over thirty European countries in various areas of life (personal and social wellbeing, welfare, values, trust in institutions, evaluation of social subsystems' operations, work-family relationship, economic morality, etc.).

The goal of the EATRIS is to establish a top-quality international infrastructure for translational research in biomedicine, including pharmacy. It promotes innovation and a vision of seeking new business opportunities in relation to biomedical research, the development of drugs and the optimisation of their use, and facilitates the simpler, better and more effective integration of individual researchers and research centres across Europe.

The ELIXIR builds and maintains a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine and the environment, the bio-industries and society. As part of ELIXIR, basic and specialist biological data is obtained, tools and services for integrating data of various origin are available, and training for various users is also provided and very active.

The SiMBioN (Slovenian Multimodal Bioimaging Node) research infrastructure consortium is composed of infrastructure centres and research teams dealing with imaging analysis of biological samples. The consortium's main mission is to provide access to state-of-the-art biological, biochemical and medical imaging technology to users in Slovenia and elsewhere coming from both research institutes and industry, and to human and veterinary medicine departments.

The E-RIHS is the European Research Infrastructure for Heritage Science. This distributed (dispersed) research infrastructure network supports research on heritage interpretation, preservation and management.

Through its member faculties, UL is also involved in the following international infrastructure programmes: CLARIN, which enables extensive and easily accessible storage of language resources and technologies covering all the member states' languages and languages that are taught in the member states or are relevant due to migration flows;

LifeWatch, which has been designed to support research on the protection, management and sustainable use of biodiversity and ecosystems;

EPOS, whose aim is to monitor and observe geophysical and earthquake phenomena;

PRACE, which is a European response to the need for increasingly greater computing power in science and industry, which can no longer be optimally provided for by purchasing higher-performance computers alone, and

DARIAH, which facilitates and promotes comparative international and interdisciplinary digital research in the arts and humanities in Europe.

From 2023 on UL also participates as a partner in the national consortium for European infrastructure Instruct-ERIC for the field of structural biology.