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Interdisciplinary doctoral programme in BIOMEDICINE
Curriculum and schedules

The programme consists of organised forms of teaching and research. Organised teaching comprises of 60 credits; the remaining 120 credits are intended for individual research work (IRW) for the doctoral thesis.

Faculty members organize and provides for implementation of the doctoral programme in fields they coordinate and in collaboration with the mentor take care for research work of the student.

The structure of the programme is designed to emphasise organised study in the first year and beginning of second year, while later the emphasis is on research and the preparation of the doctoral thesis.
 

Year 1

Credits

Year 2

Credits

Year 3

Credits

Core courses

30

Elective courses

15

IRW

50

IRW

30

Presentation of the doctoral dissertation topic

5

A presentation of the result of doctoral dissertation

5

 

 

IRW

40

Completed doctoral dissertation and public defence

5


In the first year of study, doctoral candidates, within the framework of core courses obtain fundamental theoretical knowledge and expertise of scientific work. 20 ECTS has to be from the core course of scientific field they are enrolled into. 10 ECTS can be chosen from other core courses.

In the second year of study, students fulfil their obligations arising from the elective course (15 ECTS). The selected courses according to student`s research work must be approved by the mentor. 
 

Registration of topic

Students should register the topic of doctoral thesis no lether then in beaging of second semester of second year  of studies.

Registration of topic of doctoral thesis as well as evaluation of each doctoral thesis are in the domain of the faculty senate responsible for a given scientific field. The Senate of the University of Ljubljana has to consent to the doctoral dissertation topic and the proposed mentor.

The focus of the third year is research work, and preparation and defence of the doctoral thesis. 
 

Mobility

Students are allowed to select 10 ECTS from elective courses from other doctoral programmes at the University of Ljubljana and comparable programmes of foreign universities. The selected courses must be approved by the mentor and the coordinator of the specific scientific field. Elective credits can be selected also from the university pool of the generic skills courses, listed at the web site of the University of Ljubljana.

The programme is composed of three types of courses:

The doctoral candidates, together with their mentors and the field coordinators, design individual study programmes by selecting courses from core and both types of elective course pools. The core courses are modular. For each scientific field a choice of at least 20 credits is needed from the core modules proposed by the respective scientific fields, while the remaining 10 credits can be chosen from modules of other core courses. Remaining credits can be obtained from the selection of various elective courses. Elective credits can also be selected from the university pool of generic skills courses, listed at the web page of the University of Ljubljana.


Core courses

Core courses are designed for each specific scientific field. The content of courses is chosen on the basis of the research work of the professors.

Each scientific field proposed at least one core course, which is as a rule constructed from modules. The selection of modules is made in agreement with the mentor and the field coordinator.

Core courses

Code

Scientific field

Course title

J-1-400

Basic Medicine

Medical Cell Biology

B-1-100

Biochemistry and Molecular Biology

Selected advanced topics in Biochemistry and Molecular biology

L-1-300

Clinical Biochemistry and Laboratory Biomedicine

Algorithms of clinical biochemical diagnostics

K-1-500

Clinical Medicine

Research in clinical medicine

G-1-600

Genetics

Genetics

M-1-410

Microbiology

Selected Topics in Microbiology

N-1-540

Neurosicience

Neurosicience

F-1-200

Pharmacy

Pharmaceutical sciences

S-1-420

Public health

Research aspects of public health

T-1-340

Toxicology

Toxicology

V-1-700

Veterinary Medicine

Regulation processes in healthy and diseased animals

 

Code: J-1-400
Course title: Medical Cell Biology                                                                                                                      

Contents:
The course Medical Cell Biology enables in depth study of cell structures and functions, their alterations during pathological processes at molecular level, and upgrading of that knowledge in some important areas of medicine. The course consists of the obligatory module Fundamentals of medical cell biology and four elective modules: Cell biology in human reproduction, Biology of malignant cells and translational oncology, Cell biology in clinical genetics and System medicine of multifactorial disorders such as human reproductive biology, Oncology, genetics and multifactorial disorders. The course is composed of a core module (Module 1) and four elective modules.

Module 1: Fundamentals of medical cell biology
The basic module focuses on cell and molecular mechanisms of normal and abnormal cell cycle, cell death, the role of cell junctions in development, differentiation and diseases, the role of cell compartments of biosynthetic and endocytotic pathway in normal and transformed cells, the role of peroxisomes and mitochondria and on the structure and function of cytoskeleton during cell differentiation and their role in various diseases.

Module 2: Cell biology in human reproduction
The module deals with the development of gonads, oogenesis, folliculogenesis, spermatogenesis, fertilization, embryogenesis. Students get knowledge on assisted reproduction and stem cells.

Module 3: Biology of malignant cells and translational oncology
Students acquire knowledge on fundamentals of cancer biology, carcinogenesis, principles and targets for cancer treatment, new treatment approaches and advances in translational oncology.

Module 4: Cell biology in clinical genetics
The module covers genetic defects in different areas of the cell function and their impact on the disease development. Such knowledge is crucial for adequate treatment decisions, follow-up of the patients and prognosis, as well as for genetic counselling.

Module 5: System medicine of multifactorial disorders
The module 5 consists of work on the project, which is based on the most recent scientific discoveries and research interests of the study group. The study focuses on the systems approaches of the post-genome era, the computation with large datasets, statistics, data modelling and on the role of global genome studies for the predictive personalized medicine.

Code: B-1-100
Course title: Selected advanced topics in Biochemistry and Molecular biology

Contents:
Core course entitled »Selected advanced topics in Biochemistry and Molecular biology« is devided into three independent modules,each equivalent to 10 ECTS:

Module 1: Selected metabolic processes with regulatory mechnisms
Included are topics on metabolism of xenobiotics and ROS, mitochondrial biogenesis, growth, ontogenetic development in mammals, struture and functional assimetry of biological membranes, membrane microdomains, protein interaction with lipid membranes, and mechanisms of signal transduction in regulating cellular processes.

Module 2: Strucure and function of biological molecules
Included are topics in molecular immunology and proteolysis.Techniques of protein engineering and molecular modelling of proteins for prediction of their function will be presented.

Module 3: Functional genomics and proteomics
Included are topics on genome structure, organization and regulation, comparative genomics and principles of global genome analysis. Theoretial principles and experimental approaches of transgenesis, transcriptomics, proteomics, metabolomics, interactomics and bioinformatics will be presented.

Students can sign in all three modules (30 ECTS) or at least two of them while the remaining 10 credits can be selected from modules offered in other core courses.

Code: L-1-300
Course title: Algorithms of clinical biochemical diagnostics

Contents:
Course is organized into three modules consisting of eight independent blocks (each 5 ECTS). Student can select any combination of blocks Each block is independently evaluated by separate score. For this research field each student have to elect 4 to 6 blocks.

Module 1: Laboratory biomedicine consists of two blocks.
Block 1: Scientific approaches in laboratory medicine, where students will learn the inductive and deductive approaches to problem solving in laboratory medicine. Using model cases, the students will critically evaluate their hypotheses, the credibility of the obtained results and the methodology used.

Block 2: Stepwise approach to clinical and biochemical diagnostics with interpretation will introduce students to the use of various mental pathways and stepwise approach in the laboratory diagnostics of common disorders. Based on this knowledge the student will be able to make evidence-based proposals for guidelines patients management.

Module 2: Molecular markers of diseases consists of three blocks.
Block 1: Common genetic diseases. Students will learn the screening (prenatal and postnatal diagnosis, family and population studies) and confirmatory tests of accumulating or missing metabolites and the correlation of laboratory results with the clinical symptoms of model diseases.

Block 2: Immune diseases. Students will learn the laboratory approaches to the diagnosis of immune-mediated diseases and hypersensitivity states using the analytes and tests in primary and targeted search for immune system disorders.

Block 3: Malignant disorders. Students will learn the use of biological molecules in the screening tests, tumor markers, extracellular tumor DNA, use of DNA / RNA tests, immunological tests, biosensors and microarrays, preparation of monoclonal antibodies, aptamers, siRNA, RNA / DNA probes and recombinant proteins in the diagnosis of malignancy.

Module 3: Translational Biomedicine consists of three blocks.
Block 1: Pharmacogenomic diagnostics. Students will learn the approaches to pharmacogenomic diagnostics and individualized therapy, pharmacogenomics of metabolic enzymes, receptors, transporters, miRNA and the direct and reverse pharmacogenomics in drug design, target identification and in preclinical and clinical studies.

Block 2. Cellular and Tissue Engineering. Students will understand different approaches in the preparation of complex cell and tissue cultures intended for advanced treatments or as system for testing artificial substances and materials in vitro.

Block 3: “Omic” Technologies and Tools (advanced technologies and tools in translational biomedicine. Students will learn about the advanced technologies in the areas of genomics, transcriptomics, proteomics and metabolomics and their implementation to laboratory practice and biomedicine.

Code: K-1-500
Course title: Research in clinical medicine

The subject is divided in three consecutive modules (each brings 10 ECTS):

Module 1: Methods in medical research
Module 1 is uniform for all students of the subject; the other two modules are composed of several thematic blocks which run parallel; the student chooses one thematic block per module.The module Methods in medical research deals with several methods, important in clinical research.

Module 2: Basic science in medical research
Basic science in medical research contains five thematic blocks dealing with theoretical background of different areas of clinical research (physiology of cardiovascular system, respiratory physiology, physiology and biomechanics of locomotor system, basic and clinical pharmacology, immunology).

Module 3: Achievements in clinical research
Achievements in clinical research contains four thematic blocks, representing research in some clinical fields (cardiovascular medical science, medical science of surgical disciplines, pneumology, medical and clinical immunology).


Code:
G-1-600
Course title : Genetics

Contents:
The »Genetics« core course is intended to provide students with solid foundations in transmission (Mendelian), microbial, molecular genetics, cytogenetics, population, quantitative, evolutionary genetics, epigenetics, genomics, and in use of bioinformatics tools in genetic analyses.

Module 1: Genetic concepts I covers various basic genetic concepts and fields of biological systems from microbes to mammals.

Module 2: Genetic concepts II provides an advanced course on theoretical and applied genetics as well as contemporary genomics. Emphasis is on analyses of genome structure or variation and applications in biomedicine and biotechnology.

Module 3: Bioinformatics tools is aimed at teaching students how to efficiently use some of the main bioinformatics tools and databases for genetic, genomic and protein analyses. Emphasis of the module is on practical problem-based projects. In summary, contents covered in the three modules of the genetics core course should provide students with the necessary skills and knowledge of contemporary concepts and scientific approaches used in classical and genomic analyses. Students should be able to apply this knowledge and expertise to tackle their projects on model organisms, microbes, domestic animals, plants, wildlife or humans. 
 

Code: M-1-410
Course title: Selected Topics in Microbiology

Contents:
The subject »Selected Topics in Microbiology« deals with complex relationships between microorganisms, between microorganisms and their hosts, and between microorganisms and their natural environment using selected cases and examples.

The subject is divided into three modules each evaluated with 10 credits (ECTS). The students inscribe the subject (30 ECTS) as a combination of three or selection of at least two modules.

Module 1: Basic medical microbiology
The structure and function of microorganisms in physiological and pathological circumstances and the mechanisms that underlay the development of human microbial diseases will be presented.

Module 2: Clinical microbiology
Diagnostic algorithms in clinical microbiology, critical interpretation of the results of microbiological testing, most frequent errors made when ordering microbiological tests and their medical and econimic consequences and problems with communication between the laboratory and clinicians will be presented.

Module 3: Microbial identification, diversity, and evolution
Traditional, molecular and polyphasic taxonomy, microbial diversity (bacterial and archaeal diversity as well as the diversity of eukaryotic microorganisms i.e. algal, fungal and diversity of protists) along with topics from molecular evolution will be presented.

Code: N-1-540
Course title: Neurosicience

Contents:
The course entitled Neuroscience reviews updated knowledge and research implementing findings from basic and clinical neuroscience that are of importance for the development of new methods of diagnosis, treatment and rehabilitation of neurological, psychiatric and neurosurgical diseases. It deals with neurobiology at the molecular, cellular and systemic level, as well as with the neurological, neurosurgical and psychiatric diseases, including ethical considerations. Students will get acquainted with research of Slovenian researchers in the field. They will present areas where they achieve tangible results at the global level. This will be followed by project-oriented and seminar work. Presentation of the seminars will be devoted to learning the skills of communicating research results to peer researchers, as well as to researchers from other fields of science and through the mass media. The course will include demonstration of laboratory procedures and pertaining state of the art equipment. The student will gain skills and competences for a systematic approach to the study of complex neuroscientific problems with the full exploitation of the methodological potential.

Module 1: Basic neuroscience

Module 2: Clinical neuroscience module which consists of three thematic sections, entitled Neurology, Psychiatry and Psychology.

Code: F-1-200
Course title: Pharmaceutical sciences

Contents:
The core course ''Pharmaceutical sciences'' deals with scientific principles of medicinal chemistry, pharmaceutical biology, pharmaceutical technological operations, delivery systems and pharmaceutical nanotechnology, molecular biopharmacy and health economics, social pharmacy, pharmacoeconomics and pharmacoepidemiology.

The core course comprises 15 independent modules, each equivalent to 15 ECTS. The students can select a combination of modules (10 ECTS each) depending on their research topic.

Modules:
Module 1.1: Drug structure and their properties
Module 1.2. Drug targets and interactions
Module 1.3: Drug design methodologies
Module 2.1: Biomolecules as targets for diagnosis and therapy
Module 2.2.: Biological and gene medical products
Module 2.3.: Herbal medicines
Module 3.1.: Pharmacokinetics and its role in drug discovery and development
Module 3.2: Biopharmaceutical analysis of LADME processes
Module 3.3. Pharmacokinetic-pharmacodynamic analysis.
Module 4.1.: Pharmaceutical manufacturing proceses
Module 4.2.: Drug delivery systems
Module 4.3.: Pharmaceutical nanotechnology and nanomedicines
Module 5.1.: Social pharmacy
Module 5.2.: Health economics
Module 5.3.: Pharmacoepidemiology

Short presentations of modules of the core course »Pharmaceutical sciences«.

Code: S-1-420
Course title: Research aspects of public health

Contents:
The course consists of two modules, 10 ECTS each.

Module 1: Determinants of health and disease
Biological background of health problems, determinants of health (lifestyle, work environment), selected health problems (mainly cancer and mental health), groups at risk, research methodology.

Module 2: Methodology of public health interventions
Health systems and health policy, health planning, quality of care, health promotion, prevention (vaccination, screening, epidemiological monitoring), primary care, rehabilitation, research methodology.

Code: T-1-340
Course title: Toxicology

Contents:
Understanding the mechanisms how chemicals disrupt biological targets is increasingly important in deciding on the safe use of chemical in the workplace and in everyday life.

The course attempts to introduce on the selected cases: mechanisms of transport of compounds across the cell membrane and toxic effects of compounds on it; the role of metabolism in the formation of reactive metabolites that covalently interact with macromolecules of cells; the role of radicals and substances capable of redox reactions to generate oxidative stress in cells; mechanisms of necrotic and apoptotic cell death induced by compounds; specific/nonspecific activation of enzymes and receptors caused by xenobiotics; toxic effects of compounds on mitochondria and peroxisomes, and energy state of cells; specific and nonspecific interactions (covalent /noncovalent) of substances with macromolecules in relation to the toxic effects of compounds (genotoxicity, immunotoxicity, etc.); mechanisms of toxic action of various groups of xenobiotics, which occur in the environment in different groups of organisms (bacteria, animals, plants, fungi); the application of biosensors and biomarkers for evaluation of the toxicity of compounds in conjunction with the corrupting effects on individual organisms, populations, community and ecosystem.

The course is devided into three independent modules, each equivalent to 10 ECTS. Students can sign in all three modules (30 ECTS) or at least two of them while the remaining 10 credits can be selected from modules offered in other core courses.

Module 1: Relationship between structure and toxicity
Covalent and noncovalent interactions of xenobiotics with macromolecules in living cells will be presented and formation of reactive oxygen compounds will be discussed in relation with genotoxic and immunotoxic effects of the compounds. Biotransformation reactions of the substance (functionalisation and conjugation) will be explained, and the consequences of the presence of their products in different tissues will be discussed. The role of radicals in the cell will be presented and the groups of substances that allow their formation will be discussed. We will also present some of the xenobiotics that non-specifically or specifically interact with cell macromolecules. Basic understanding of toxicological tests, including the quantum mechanic methods and bimolecular simulations that allow toxicity prediction of substances will be presented.

Module 2: Influence of toxic compounds on processes within cell
Discussed The effects of substances on the transport across membranes will be discussed, and the mechanisms of necrotic and apoptotic cell death induced by xenobiotics will be explained. The toxicity of a substance caused by the activation / suppression of cytokine and nuclear receptors will be described. The examples of xenobiotics that interfere with the processes of energy and interact with mitochondria and peroxisomes, immune system and genetic material will be presented.

Module 3: Influence of toxic compounds on environment and ecosystems
In this module will be presented: effects of xenobiotic on suborganism, organism, population and ecosystem level; extrapolation of toxicological data from molecular and physiological levels to higher levels of biological organization; bioavailability of xenobiotics and other harmful substances in soil and water; biotransformation way of some important groups of xenobiotics and other harmful substances in soil and water; path intake of residues of drugs and their metabolites in the environment, their behavior (adsorption/desorption, distribution, decomposition) and their toxic effects in the environment; the possibility of bio-accumulation and toxic effects of residues of substances in aquatic and terrestrial organisms in the environment.

Code: V-1-700
Course title: Regulation processes in healthy and diseased animals

Contents:

Module 1: Regulation of basic processes in animals
It deals with morphological and functional characteristics of animal cell, cell as hereditary carrier, cell response to environment influence, intercellular communication and regulation of genetic expression, defensive and metabolic mechanisms of cells, in vitro cell investigation, homeostasis and homeoresis, neuro-hormonal regulation of physiological processes, neural and endocrine regulation of digestion and metabolism, regulation of blood parameters, regulation of blood circulation and respiration, adaptation to body aggravation, regulation of excretion, regulation of body temperature, link between endocrine, nerve and immune system, mechanisms of nerve and sensual perception in domestic animals, progenesis, fecundation and early embryonic development in domestic animals.

Module 2: Disruption of homeostasis and disease processes
It deals with basic reasons for disturbances and elementary pathophysiological processes in organisms significant for comprehension of disease development and definition of clinical diagnosis and therapy; recognition of altered organism functioning by morphological changes of tissues and better understanding of organism reactions in sickness; biochemical parameters as indicators of liver, kidney, muscle, gastrointestinal tract; mineral and electrolyte metabolism and estimation of acid-bases balance; changes of processes in animals due to nutritional admission of harmful substances, pathogenic microorganisms, micotoxins, natural toxic substances, healing supplements and radionuclides and their regulation.

Module 3: Food safety
The purpose of education is to gain knowledge and understanding of positive and negative effect of interaction between man and animal, with an emphasis on eating foods of animal origin, using epidemiological and statistical tools to estimate the risk, gain of new knowledge in the technology of meat and dairy processing industries, as well as fish processing industry, clams, crabs, frogs, eggs, honey and products from these commodities.
 

Elective courses

The various scientific fields offer a great variety of elective courses. The candidate can choose between elective theorethical courses and elective individual research courses evaluated with 5 credits. The courses are offered by professors who are at the same time leading scientists in their respective scientific fields. Elective individual research courses are offered by researchers who can accept doctoral candidates in their laboratories, where they can aquire up-to-date scientific technologies and approaches to experimental work. A total of

10 elective credits can be selected from the university pool of generic skills courses, listed at the web page of University of Ljubljana (http://bit.ly/doktorski_studij).

Elective theoretical courses

 

Course

Lecturer

Code

1

Advanced drug delivery systems

Julijana Kristl

F-2-229

2

Advanced molecular genetics

Jože Pungerčar

B-2-902

3

Analysis of drugs and metabolites in biosystems

Albin Kristl

F-2-202

4

Animals in experiment

Mitja Gombač

V-2-708

5

Applied microbial enzymatics

Romana Marinšek Logar

M-2-617

6

Autoimmunity

Borut Božič

L-2-301

7

Biochemistry of biological membranes

Igor Križaj

B-2-903

8

Biogenic medicines

Damjan Janeš

F-2-203

9

Biomolecular thermodynamics

Jurij Lah

B-2-800

10

Biophysics of macromolecules and membrane

Janez Štrancar

F-2-923

11

Cell and tissue engineering in advanced therapies

Matjaž Jeras

F-2-204

12

Cell physiology

Robert Zorec

B-2-105

13

Chosen chapters from drug analysis

Aleš Obreza

F-2-217

14

Clinical biochemistry – selected topics

Janja Marc

L-2-302

15

Clinical pharmacokinetics

Aleš Mrhar

F-2-225

16

Communicology in pharmacy

Mitja Kos

F-2-206

17

Compounds with multiple mode of action

Janez Ilaš

F-2-240

18

Cosmetology – selected topics

Mirjana Gašperlin

F-2-219

19

Design and analysis of clinical and epidemiological research

Lara Lusa

J-2-466

20

Design and synthesis of enzyme inhibitors

Stanislav Gobec

F-2-227

21

Design of biodiagnostics and biosensors

Janko Kos

L-2-303

22

Drug design

Danijel Kikelj

F-2-230

23

Drug stability

Robert Roškar

F-2-235

24

Electron paramagnetic resonance in biological systems

Janez Štrancar

F-2-922

25

Electroporation based technologies and treatments

Damijan Miklavčič

J-2-441

26

Entrepreneurship in medicine

Mateja Drnovšek

B-2-108

27

Ethology and reserach methods in animal behaviour

Martin Dobeic

V-2-704

28

High resolution optical microscopy – confocal microscopy

Marko Kreft

J-2-440

29

Industrial development of dosage forms

Janez Kerč

F-2-215

30

Industrial medicinal chemistry

Stanislav Gobec

F-2-237

31

Interactions of drug delivery systems in biosystems

Marija Bogataj

F-2-216

32

Introduction to data mining

Blaž Zupan

L-2-126

33

Light and electron microscoply

Rok Romih

J-2-465

34

Macromolecular crystallography

Dušan Turk

F-2-920

35

Medical biophysics

Jure Derganc

J-2-442

36

Medical virology

Mario Poljak

M-2-413

37

Methods for determination of phenomena at interfaces

Odon Planinšek

F-2-226

38

Methods of  structure and properties determination of drugs

Tomaž Šolmajer

F-2-921

39

Microbiology of the gut

Gorazd Avguštin

M-2-616

40

Molecular bioinformatics

Roman Jerala

B-2-901

41

Molecular biology in veterinary medicine

Jelka Zabavnik Piano

V-2-706

42

Molecular mechanisms of cancer

Gregor Serša

B-2-107

43

Monoclonal antibodies - the overview and their use in research, diagnostics and therapy

Vladka Čurin Šerbec

B-2-106

44

Mutagenesis and genetic toxicology

Metka Filipič

T-2-940

45

Perinatology

Ksenija Geršak

K-2-536

46

Pharmaceutical biotechnology

Borut Štrukelj

F-2-205

47

Pharmaceutical packaging

Stane Srčič

F-2-234

48

Pharmacoeconomics

Mitja Kos

F-2-208

49

Pharmacogenetics and personalized medicine

Vita Dolžan

B-2-104

50

Pharmacogenomics in pharmaceutical practice

Irena Mlinarič - Raščan

F-2-209

51

Pharmacometrics

Mitja Kos

F-2-210

52

Pharmacotherapy

Aleš Mrhar

F-2-201

53

Physiology and ecology of fungi

Nina Gunde-Cimerman

M-2-618

54

Probiotics

Romana Marinšek Logar

M-2-619

55

Protein folding and aggregation

Eva Žerovnik

B-2-905

56

Quality assurance and validations in pharmaceutical production 

Stane Srčič

F-2-214

57

Quality of care assessment research methods

Marija Petek Šter

S-2-423

58

Quality of medicaments

Aleš Krbavčič

F-2-224

59

Reactive metabolites of xenobiotics

Lucija Peterlin Mašič

T-2-345

60

Selected topics from oromaxillofacial field

Nataša Ihan Hren

 K-2-535

61

Selected topics in drug synthesis

Danijel Kikelj

F-2-220

62

Social pharmacy with pharmacoepidemiology

Mitja Kos

F-2-238

63

Steroid hormones and hormone dependent diseases

Tea Lanišnik Rižner

B-2-109

64

Synthesis and analysis of chiral drugs

Danijel Kikelj

F-2-239

65

The biology of stress

Damjana Drobne

T-2-344

66

The methodology of scientific research

Jelka Zabavnik Piano

V-2-705

67

Thermal analysis  of pharmaceuticals

Stane Srčič

F-2-228

68

Topics from physical pharmacy

Stane Srčič

F-2-218

69

Transport and metabolism of drugs in biosystems

Albin Kristl

F-2-236

70

Veterinary dosage forms

Stane Srčič

F-2-207

71

Veterinary ecology and biosecurity

Martin Dobeic

V-2-707

 

Elective individual research courses

 

Course

Lecturer

Code

1

Allergology

Mitja Košnik

K-3-501

2

Basic of molecular virology

Ivan Toplak

V-3-726

3

Biological implications of protein aggregation

Eva Žerovnik

B-3-910

4

Biological implications of protein misfolding and aggregation

Eva Žerovnik

B-3-911

5

Biology and diseases of  honeybee society

Vlasta Jenčič

V-3-709

6

Biophysics of biological processes, cells and tissues

Zoran Arsov

F3925

7

Biotechnological processes in pharmacy

Borut Štrukelj

F-3-245

8

Breeding and health care of wild animals

Gorazd Vengušt

V-3-716

9

Cardiovascular dynamics

Borut Kirn

K-3-509

10

Cell cultures in research studies and regenerative medicine

Mateja Erdani Kreft

J-3-463

11

Cell electrophysiological methods

Robert Zorec

N-3-546

12

Cellular models of stress

Irina Milisav Ribarič

J-3-453

13

Characterization and identification of microfungi

Nina Gunde-Cimerman

M-3-621

14

Clinical aspects of human reproduction

Bojana Pinter

K-3-511

15

Clinical biochemistry – selected contents

Janja Marc

L-3-313

16

Clinical cardiac electrophysiology

Peter Rakovec

K-3-512

17

Clinical neurophysiological methods for assessment of muscles and the nervous system

David B. Vodušek

N-3-548

18

Clinical neurosonology methods for cerebrovascular blood flow study

Bojana Žvan

N-3-549

19

Community care

Vesna Švab

S-3-427

20

Comparative genomics

Jernej Jakše

G-3-613

21

Comparative odontology and periodontal medicine

Zlatko Pavlica

V-3-727

22

Comparison of fluorescence and electron microscopy applications in protein research in immune cells

Tina Zavašnik Bergant

B-3-904

23

Concepts of genomic data integration

Tanja Kunej

G-3-609

24

Congenital heart disease

Mirta Koželj

K-3-516

25

Contemporary methods in small animal emergency medicine

Alenka Seliškar

V-3-729

26

Cryomethods in biomedicine

Rok Romih

J-3-443

27

Dermatology of dogs and cats

Tina Kotnik

V-3-712

28

Design and experimental research of cancer diseases

Petra Hudler

B-3-113

29

Detection and localisation of molecules in cells

Peter Veranič

J-3-457

30

Determination of specific protein expression in skeletal muscle cells with western blot  

Tomaž Marš

J-3-448

31

Development of biomarkers and their clinical application

Joško Osredkar

L-3-317

32

Diagnostic and experimental cytology

Margareta Strojan Fležar

J-3-456

33

Diagnostic microbiology

Mario Poljak

M-3-414

34

Diagnostics and intensive therapy of neurological diseases in newborn

David Neubauer

N-3-547

35

Diseases and fish health management

Vlasta Jenčič

V-3-710

36

Diseases of birds, small mammals and reptiles

Joško Račnik

V-3-711

37

Drug stability

Robert Roškar

F-3-254

38

Echocardiography

Mirta Koželj

K-3-502

39

Exsperimental techniques in dental prosthodontics

Peter Jevnikar

K-3-529

40

Electronic analog circuitry for physiological and pathophysiological studies

Samo Ribarič

K-3-517

41

Electrophysiologic study of the visual system

Jelka Brecelj

N-3-552

42

Enzyme catalysis

Jure Stojan

B-3-124

43

Evidence based work in nursing and health
service

Brigita Skela Savič

S-3-429

44

Evidence-based laboratory medicine

Janja Marc

L-3-314

45

Evolutionary genomics

Dušan Kordiš

B-3-909

46

Experimental methods in laboratory medicine

Darko Černe

L-3-309

47

Experimental approaches in molecular genetics diagnostic of inborn disorders

Katarina Trebušak Podkrajšek

G-3-611

48

Experimental approaches in the study of complex microbial communities and their interactions

Gorazd Avguštin

M-3-620

49

Experimental epigenetics

Alja Videtič Paska

B-3-115

50

Experimental immunology

Alojz Ihan

K-3-504

51

Experimental methods for studying biochemistry of steroid hormones

Tea Lanišnik Rižner

B-3-122

52

Experimental methods for the research of brain disease

Marko Živin

N-3-545

53

Experimental methods in biophysics

Janez Štrancar

F-3-924

54

Experimental methods in pharmacogenomics

Vita Dolžan

B-3-110

55

Experimental metods in innate immunity

Roman Jerala

B-3-908

56

Experimental metods in studies of nucleic acid structure

Janez Plavec

B-3-116

57

Experimental neuroendocrinology

Gregor Majdič

V-3-713

58

Experimental rheological analysis

Mirjana Gašperlin

F-3-249

59

Experimental virology

Tatjana Avšič-Županc

M-3-415

60

Experimental approach in studies of signal transduction

Ana Plemenitaš

B-3-111

61

Food safety

Andrej Kirbiš

V-3-724

62

Functional MRI

Dušan Šuput

N-3-557

63

Functional protein analysis in signal transduction

Aljoša Bavec

B-3-112

64

Gastroenterologic surgery

Mirko Omejc

K-3-506

65

Gastrointestinal problems in horses

Peter Kruljc

V-3-715

66

Genome analysis of complex traits

Gregor Gorjanc

G-3-606

67

Genome and transcriptoem analyses

Damjana Rozman

B-3-119

68

Genome editing and regulating gene expression using TALEs and CRISPR/Cas9

Roman Jerala

G-3-931

69

Genomewide association and functional analysis in human

Uroš Potočnik

G3610

70

Haematology – selected topics

Peter Černelč

L-3-304

71

Health care of pigs

Marina Štrukelj

V-3-739

72

Health care of ruminants

Jožica Ježek

V-3-740

73

Hemostasis

Mojca Stegnar

K-3-526

74

Hereditary disorders of the skin – molecular techniques for disease diagnosis and research

Mirjana Liovic

B-3-118

75

High resolution electrocardiography

Vito Starc

K-3-503

76

High resolution optical microscopy – confocal microscopy

Marko Kreft

J-3-446

77

Homemade site directed mutagenesis

Darja Žgur-Bertok

B-3-120

78

Human cytogenetics

Nadja Kokalj Vokač

G-3-608

79

Hygiene and pathology of animal nutrition

Breda Jakovac Strajn

V-3-725

80

Immune reaction in research and diagnostics

Saša Čučnik

L-3-306

81

Immunohistochemistry

Mija Meznarič

J-3-451

82

Inhibitors of enzyme-catalyzed reactions

Brigita Lenarčič

B-3-801

83

Intracellular signalling mediated by receptor and non-receptor protein kinases

Zoran Grubič

J-3-458

84

Macromolecular interactions

Gregor Anderluh

B-3-906

85

Mammary gland: a model for genetic, developmental and cell biology studies

Peter Dovč

G-3-604

86

Methods for determination of antithromboctic efficiency of agents

Mojca Stegnar

F-3-247

87

Methods for determination of reactive metabolites of xenobiotics

Marija Sollner Dolenc

T-3-348

88

Methods in single cell physiology

Robert Zorec

J-3-445

89

Metods and models in cell-based assays

Irena Mlinarič Raščan

L-3-305

90

Microbiology

Andrej Pengov

V-3-721

91

Microbiology techniques

Matjaž Ocepek

V-3-722

92

Molecular analysis and suicidal behavior

Alja Videtič Paska

B-3-114

93

Molecular diagnostics

Damjan Glavač

J-3-461

94

Molecular diagnostics in laboratory biomedicine

Barbara Ostanek

L-3-316

95

Molecular genetics of hormone in metabolic disorders

Tadej Battelino

B-3-123

96

Molecular methods in pharmacology

Metoda Lipnik-Štangelj

K-3-513

97

Monitoring of DNA amplification in real time

Kristina Gruden

G-3-607

98

Morphology and function of peripheral nerves

Simon Podnar

N-3-550

99

Morphometric analysis of cells and tissues

Milka Vrecl

V-3-723

100

Neurochemical methods

Zoran Grubič

N-3-553

101

Neurology and neurophysiology during early developmental age

David Neubauer

N-3-554

102

Nuclear magnetic resonance in studies of biological macromolecules

Janez Plavec

B-3-907

103

Numerical modeling of processes in biophysics

Bojan Božič

J-3-460

104

Nutrigenomics

Nataša Karas Kuželički

L-3-315

105

Osteosynthesis

Vladimir Smrkolj

K-3-515

106

Pathobiochemical mechanisms and models

Samo Ribarič

L-3-308

107

Pharmacoeconomics

Mitja Kos

F-3-256

108

Pharmacological and  toxicological testing of drugs

Metoda Lipnik-Štangelj

K-3-505

109

Pharmacology and toxicology

Silvestra Kobal

V-3-714

110

Pharmacotherapy

Aleš Mrhar

F-3-255

111

Plant toxins and poisonous plants

Samo Kreft

T-3-349

112

Poultry health and protection

Olga Zorman Rojs

V-3-738

113

Preparation of skeletal muscle cell culture

Tomaž Marš

J-3-449

114

Principles and techniques in biochemistry and molecular biology

Brigita Lenarčič

B-3-802

115

Problems in ruminant medicine or surgery

Jože Starič

V-3-718

116

Protein glycosylation

Gregor Gunčar

B-3-805

117

Protein structure

Gregor Gunčar

B-3-804

118

Qualitative methods on health behaviour research

Marko Kolšek

S-3-424

119

Qualitative research through interviews

Danica Rotar Pavlič

S-3-425

120

Quality design and quality assurance in medical laboratories

Joško Osredkar

L-3-307

121

Rational design of peptidomimetics

Marija Sollner Dolenc

F-3-248

122

Reactive oxygen and nitrogen species in biological systems

Janez Mravljak

F-3-244

123

Recombinant proteins

Marko Dolinar

B-3-803

124

Recommendations on the implementation of point-of-care tests

Joško Osredkar

K-3-527

125

Regulation of gene expression – experimental approaches

Damjana Rozman

B-3-121

126

Regulation of gene expression of prokaryotes

Darja Žgur-Bertok

G-3-612

127

Reproduction and obsterics

Marjan Kosec

V-3-728

128

Research approach to diagnositcs and therapy of cerebrovascular disease

Janja Pretnar Oblak

N-3-556

129

Research designs in health promotion

Lijana Zaletel - Kragelj

S-3-426

130

Screening tests for Down syndrome

Joško Osredkar

J-3-447

131

Selected cases in medical genetics

Damjan Glavač

B-3-125

132

Selected cases in human genetics

Damjan Glavač

G-3-605

133

Selected immunological methods

Alojz Ihan

K-3-508

134

Selected methods applied in sports medicine

Helena Lenasi

K-3-528

135

Selected methods in pharmacokinetics

Mojca Kržan

K-3-507

136

Selected topics from drug analysis

Aleš Obreza

F-3-250

137

Silencing of specific genes using sirna approach

Katarina Miš

J-3-455

138

Single cell micromanipulation

Jure Derganc

J-3-459

139

Skeletal muscle analysis

Vika Smerdu

J-3-452

140

Sleep medicine and polysomnographic recordings for evaluation of sleep disorders

Leja Dolenc Grošelj

N-3-555

141

Sleep-related breathing disorders and sleep disorders during development

David Neubauer

N-3-551

142

Small animal ultrasonography

Aleksandra Domanjko Petrič

V-3-731

143

Special veterinary pathology

Polona Juntes

V-3-730

144

Stem cells: from proteomics to cell therapies

Uroš Rajčević

B-3-117

145

Stereology and quantitative image analysis

Andrej Cör

J-3-450

146

Stigma of mental disorders

Vesna Švab

S-3-428

147

Study of drug effects on human microcirculation

Ksenija Cankar

K-3-518

148

Surgery and ophtalmology

Vladimira Erjavec

V-3-719

149

Surgical oncology

Nikola Bešić

K-3-514

150

Techniques for studying membrane proteins and assesing the membrane integrity on the model of mitochondrial biogenesis

Irina Milisav Ribarič

J-3-454

151

Toxicokinetics

Iztok Grabnar

T-3-346

152

Toxicological testing of new drugs

Marija Sollner Dolenc

T-3-347

153

Toxicology on molecular scale

Janez Mavri

T-3-941

154

Treatment methods of cancer in veterinary medicine

Nataša Tozon

V-3-720

155

Tumor biology

Gregor Serša

J-3-444

156

Urogynecology

Adolf Lukanovič

K-3-519

157

Veterinary anaesthesiology

Alenka Seliškar

V-3-732

158

Veterinary cardiology

Aleksandra Domanjko Petrič

V-3-734

159

Veterinary diagnostic cytopathology

Polona Juntes

V-3-733

160

Veterinary immunology methods

Tadej Malovrh

V-3-717

161

Veterinary laboratory medicine  - clinical pathology

Bojan Zorko

V-3-735

162

Veterinary orthopedic and neurosurgery

Martina Klinkon Ogrinec

V-3-737

163

Veterinary radiology

Bojan Zorko

V-3-736

164

Work with isolated organs

Katarina Černe

J-3-462

165

Yeast genetics, functional geomics and systems biology

Uroš Petrovič

G-3-930

The core course schedules are published here in early September each year. Schedules for elective courses are designed individually.

The courses are coded with a capital letter and two numbers. The capital letter indicates the scientific field or a combination of fields. The first number indicates the type of the course and the second one consists of three digits, the first indicating the location and the last two the consecutive number of the course. 

Scientific fields:
G - Genetics
B - Biochemistry and Molecular Biology
F - Pharmacy
L - Clinical Biochemistry and Laboratory Biomedicine
J - Basic Medical Science
K - Clinical Medicine
M - Microbiology
N - Neuroscience
V - Veterinary Medicine
S – Public Health
T - Toxicology 

Types of courses:
1 – core courses
2 – elective theoretical courses
3 – elective individual research courses 

Course locations:

1 – Faculty of Medicine - Biochemistry and Molecular Biology
2 – Faculty of Pharmacy – Pharmacy
3 – Faculty of Pharmacy - Clinical Biochemistry and Laboratory Biomedicine, Toxicology
4 – Faculty of Medicine – Basic Medical Science, Public Health, Microbiology
5 – Faculty of Medicine, University Medical Centre Ljubljana, Institut of Oncology Ljubljana, University Psyhiatric Hospital Ljubljana – Clinical Medicine, Neuroscience
6 – Biotechnical Faculty - Microbiology, Genetics
7 – Veterinary Faculty – Veterinary Medicine
8 – Faculty of Chemistry and Chemical Technology
9 – research institutes: Josef Stefan Institute, Chemical Institute, National Institute of Biology

Hence, the course bearing the code B-2-940 belongs in the area of biochemistry and molecular biology (B), is an elective theoretical course (2) and is carried out at a research institute (9).

CORE COURSES:

B-1-100   Selected advanced topics in Biochemistry and Molecular biology
B-1-101     1  Selected metabolic processes with regulatory mechnisms
B-1-102     2 Strucure and function of biological molecules
B-1-103     3  Functional genomics and proteomics                 

F-1-200      Pharmaceutical sciences
F-1-211      1. 1 Drug structure and their properties
F-1-212      1. 2 Drug targets and interactions
F-1-213      1. 3 Drug design methodologies
F-1-221      2. 1 Biomolecules as targets for diagnosis and therapy
F-1-222      2. 2 Biological and gene medical products
F-1-223      2. 3 Herbal medicines
F-1-231      3. 1 Pharmacokinetics and its role in drug discovery and development
F-1-232      3. 2 Biopharmaceutical analysis of LADME processes
F-1-233      3. 3 Pharmacokinetic-pharmacodynamic analysis
F-1-241      4. 1 Pharmaceutical manufacturing proceses
F-1-242      4. 2 Drug delivery systems
F-1-243      4. 3 Pharmaceutical nanotechnology and nanomedicines
F-1-251      5. 1 Social  pharmacy
F-1-252      5. 2 Health economics
F-1-253      5. 3 Pharmacoepidemiology                

L-1-300      Algorithms of clinical biochemical diagnostics
L-1-310      1. Laboratory biomedicine
L-1-311            1. 1 Scientific approaches in laboratory medicine
L-1-312            1. 2 Stepwise approach to clinical and biochemical diagnostics with      interpretation
L-1-320      2. Molecular markers of diseases
L-1-321            2. 1 Common genetic diseases
L-1-322            2. 2 Immune diseases
L-1-323            2. 3 Malignant disorders 
L-1-330      3. Translational Biomedicine
L-1-331            3. 1 Pharmacogenomic diagnostics
L-1-332            3. 2 Cellular and Tissue Engineering
L-1-333            3. 3 Omic” Technologies and Tools (advanced technologies and tools in    translational biomedicine                

T-1-340      Toxicology
T-1-341     1. Relationship between structure and toxicity
T-1-342     2. Influence of toxic compounds on processes within cell
T-1-343     3. Influence of toxic compounds on environment and ecosystems                

J-1-400      Medical Cell Biology
J-1-401     1. Fundamentals of medical cell biology
J-1-402     2. Reproductive biology in vivo and in vitro
J-1-403     3. Biology of Malignant Cells and Translational Oncology
J-1-404     4. Cell biology in clinical genetics
J-1-405     5. Systems medicine of multifactorial disorders                

M-1-410     Selected Topics in Microbiology
M-1-411    1. Basic medical microbiology
M-1-412    2. Clinical microbiology
M-1-615    3. Microbial identification, diversity, and evolution                

S-1-420      Research aspects of public health
S-1-421      Determinants of health and disease
S-1-422      Methodology of public health interventions                 

K-1-500      Research in clinical medicine
K-1-510      1. Methods in medical research
K-1-520      2. Basic science in medical research
K-1-521          2. 1 Physiology of cardiovascular system
K-1-522          2. 2 Respiratory physiology
K-1-523          2. 3 Physiology and biomechanics of locomotor system
K-1-524          2. 4 Basic  and clinical pharmacology
K-1-525          2. 5 Immunology
K-1-530      3. Achievements in clinical research
K-1-531           3. 1 Cardiovascular medical science
K-1-532           3. 2 Medical science of surgical disciplines
K-1-533           3. 3 Pneumology
K-1-534           3. 4 Scientific principles of medical and clinical immunology                

N-1-540      Neuroscience
N-1-541      2. Basic neuroscience
N-1-542      3. 1 Clinical Neuroscience – Neurology
N-1-543      3. 2 Clinical Neuroscience – Psychiatry
N-1-544      3. 3 Clinical Neuroscience - Psychology                

G-1-600     Genetics
G-1-601     Genetic concepts I
G-1-602     Genetic concepts II
G-1-603     Bioinformatics tools                

V-1-700      Regulation processes in healthy and diseased animals
V-1-701     1. Regulation of basic processes in animals
V-1-702     2. Disruption of homeostasis and disease processes
V-1-703     3. Food safety