Master University of Ljubljana FACULTY OF PHARMACY
Email: Phone: +386 1 47 69 500
No.
Subjects in English 2023/2024 (Master)
Number of ECTS credit points
First semester (Winter / Autumn)
1
Biopharmaceutics with Pharmacokinetics
Biopharmaceutics with Pharmacokinetics
LADME system: mechanisms, kinetics, methods, physico-chemical, technologic and biologic parameters, biopharmaceutical classification system, in vitro-in vivo correlation.Pharmacokinetics, pharmacokinetic-pharmacodynamic relation. Compartmental pharmacokinetics: models, structure, parameters; single/multiple dose pharmacokinetics; one-/two-compartment models; different routes of application, pharmacokinetic analysis of plasma concentration profile and urine cumulative amount profile. Bioavailability and bioequivalence.
9
2
Pharmaceutical biotechnology
Pharmaceutical biotechnology
Modern and classical biotechnology. Basic principles of production of recombinant active substances and synthetic peptides. Function of the immune system. Cytokines. Growth factors. Monoclonal antibodies. Analytics of active substances of biotechnological origin. The use and mechanism of action of biopharmaceuticals. Plant and animal tissue and cell cultures. Gene therapy. Ethics and the regulatory process in the field of pharmaceutical biotechnology.
6
3
Pharmaceutical technology
Pharmaceutical technology
Pulmonal drug delivery, Rectal and vaginal drug delivery, Coarse dispersion systems (suspensions, emulsions), Topical and transdermal drug delivery, Pharmaceutical microbiology and sterilization, Parenteral dosage forms, Ocular drug delivery, Particle size reduction, mixing and granulation, Tablets and tablet manufacturing (compression, coating, drying), Multiparticulate dosage forms
10
4
Pharmacognosy I
Pharmacognosy I
Herbal medicinal products, their active substances and pharmacodynamic effects. Herbal substances with carbohydrates (mucilages, gums, pectins), triglycerides, essential oils, other terpenic compounds, polyalkynes, tannins, phloroglucinols, alkaloids, steroids, glycosides (cyanogenic, phenols and phenolcarboxylic acids, coumarins, flavonoids, anthraquinones, iridoids, sesquiterpene lactones, saponins, cardiac). Clinical studies in phytotherapy.
9
5
Social Pharmacy
Social Pharmacy
Public health: healthcare system, health insurance system, legislation, health promotion, ethics. Pharmacotherapy: supply and provision of medicinal products, pharmacy services, the use of medicinal products and associated problems. Pharmacoepidemiology and pharmacovigilance: risks, types of research, sampling, errors. Therapy outcomes: clinical, humanistic and economical. Evaluation of healthcare interventions.
4
6
Toxicological chemistry
Toxicological chemistry
Specific and unspecific poisons. Determination of substance toxicity. Toxicogenomics. Gene toxic, carcinogenous and co-carcinogenous substances. Immunotoxic substances. Toxicological chemistry of inhalation poisons, metals, heavy metals, organic solvents, pesticides, insecticides, herbicides, fungicides and rodenticides, chemical weapons, toxins of eukaryotes and prokaryotes, toxicomanogenous substances. Analytics of poisons. Antidotes and medicinal products.
5
Full academic year
7
Pharmaceutical technology I
Pharmaceutical technology I
Pulmonal drug delivery, Rectal and vaginal drug delivery, Coarse dispersion systems (suspensions, emulsions), Topical and transdermal drug delivery, Pharmaceutical microbiology and sterilization, Parenteral dosage forms, Ocular drug delivery, Particle size reduction, mixing and granulation, Tablets and tablet manufacturing (compression, coating, drying), Multiparticulate dosage forms. Physico-chemical properties from thermodynamic aspect; biopharmaceutical performance, Physical and chemical preformulation drug characteristics and their influence on biopharmaceutical performance, Solubility, solubilization and solubilizers, Kinetics – 1st order, 2nd order, Higuchi kinetics, Dissolution testing, Biomucoadhesion, Selected advanced drug delivery systems and devices, Pharmaceutical polymers as active pharmaceutical ingredients or pharmaceutical excipients – properties, descriptions and classification, Pharmaceutical nanotechnology, Microbiological quality of pharmaceutical products and packaging, Delivery of biopharmaceutics.
20
Second semester (Summer / Spring)
8
Biopharmaceutical evaluation of pharmaceutical forms
Biopharmaceutical evaluation of pharmaceutical forms
Pharmaceutical form: constituents, interactions. The effects of physicochemical properties on biopharmaceutical properties. Analytical methods for evaluation of biopharmaceutical properties. Physiological / pathological conditions at the site of administration. Oral administration. Digestive tract: pH, volumes, media, flows, movement. Release. Absorption. Presystemic metabolism. Stability. In vitro models. In vitro – in vivo correlation. Regulatory system. Industrial approaches.
5
9
Clinical pharmacy
Clinical pharmacy
Clinical outcomes. Pharmaceutical Care, Pharmacist cognitive services. Guidelines for the pharmacotherapy of selected diseases. Pharmacotherapy of cardiovascular diseases, asthma and chronic obstructive pulmonary disease, psychosis, depression, infections, diabetes, pain. Risks of drug treatment during pregnancy and lactation. Drug use in special populations (children, elderly). Clinical pharmacokinetics and therapeutic drug monitoring. Drug interactions and adverse drug reactions.
5
10
Cosmetology
Cosmetology
Skin: cellular structures of skin and hair, skin matrix compounds, polysaccharides, proteoglycans, skin lipids. Cosmetic products: manufacturing technology, evaluation and application. Ingredients of cosmetic products: cosmetically active compounds, surface active compounds, emulsifiers, preservatives, antioxidants. Cosmetics Act. Evaluation of safety and efficacy. Care and natural cosmetic products. Sun protection products.
5
11
Nutritional supplements
Nutritional supplements
Legislation in the area of nutritional supplements. Definitions of basic terms: nutraceuticals, functional food, diet food. Recommended daily intake of nutrients. Vitamins. Vitaminoids. Minerals. Amino acids. Lipids. Carbohydrates. Prebiotics and probiotics. Antioxidants. Bee products. Enzymes. Phytoestrogens.
5
12
Pharmaceutical technology II
Pharmaceutical technology II
Physico-chemical properties from thermodynamic aspect; biopharmaceutical performance. Physical and chemical preformulation drug characteristics and their influence on biopharmaceutical performance. Solubility, solubilization and solubilizers. Kinetics – 1st order, 2nd order, Higuchi kinetics. Dissolution testing. Biomucoadhesion. Selected advanced drug delivery systems and devices. Pharmaceutical polymers as active pharmaceutical ingredients or pharmaceutical excipients – properties, descriptions and classification. Pharmaceutical nanotechnology. Microbiological quality of pharmaceutical products and packaging, Delivery of biopharmaceutics.
8
13
Psychotropic substances and abuse of medicinal products
Psychotropic substances and abuse of medicinal products
Groups of psychotropic substances and medicinal products that are commonly subject of abuse: illicit drugs – narcotics, anabolic steroid hormones, stimulants, diuretics, analgesics, local anesthetics, anxiolytics, antidepressants, hypnotics, glycoprotein hormones. Mechanisms of action. Symptoms of overdosing. The phenomenon of tolerance, addiction and withdrawal syndrome. Methods of poisoning and antidotes. Legislation.
5
14
Research methods in social pharmacy
Research methods in social pharmacy
Evidence based medicine, evidence based pharmacy practice, Systematic review, Risk of Bias Assessment, Meta-analysis, Clinical Trials Results, Pharmacoepidemiology, pharmacovigilance, Drug Utilization Research, Study Designs, Research of Structure, Proceses and Health Outcomes, Qualitative research methods: Interview, Consensus Techniques, Questionnaire, Reliability, Validity.