Areas

Health

Fields of use

Human health. Oncology. Immunotherapy. Pharmaceutical industry. Biotechnology.

Current state of technology

Prototype

Intellectual property

Patent Application No.: LU102145

Developed by

University of Ljubljana, Faculty of Pharmacy

Reference

821-10/2020

Contact

Knowledge Transfer Office UL

Gabriela Droga Mazovec
Tel: +386 70 538 284
E-pošta: gospodarstvo@uni-lj.si

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Background

The human innate immune system contains a series of pattern recognition receptors. Among them, NOD-like receptors and Toll-like receptors are attractive targets for the development of vaccine adjuvants and drugs for the treatment of infectious diseases and cancers.

Description of invention

Our specification refers to novel conjugated compounds that act as agonists of both TLR7 and NOD2. These novel compounds function as immunostimulants and are useful for the treatment of viral, bacterial, fungal and protozoal infections, tumours or cancers and other immunological diseases. Additionally, the conjugated compounds of the invention can be used as vaccine adjuvants, compounds that enhance the host’s humoral and/or cellular immune response against the antigen.

Main advantages

Simultaneous activation of both TLR7 and NOD2 induces signal amplification, thus synergistically improving the potency of such conjugated compounds. Furthermore, besides the potent immunostimulatory effects of these compounds, our in vitro and in vivo experiments also indicate that these compounds induce both humoral and cellular immune responses, with the latter being especially important for the treatment and prevention of viral infections and cancers.