Technologies

Description

The invention proposes the use of cytolytic bi-component protein complexes derived from the fungal genus Pleurotus as an environmentally friendly and human-safe alternative biopesticide for controlling Colorado potato beetle (CPB) and Western root cornworm (WCR), pests that cause significant damage to potatoes and maize crops and are rapidly evolving resistance to current control methods.

Description

The invention introduces a new class of benzothiazole scaffold-based inhibitors targeting the ATPase domains of DNA gyrase and/or topoisomerase IV, which are effective against both Gram-positive and Gram-negative pathogens, including multi-drug resistant strains from the "ESKAPE" group, offering a promising alternative to existing treatments with lower toxicity and potential for further development.

Description

This invention presents novel conjugated compounds that act as dual agonists of TLR7 and NOD2, offering potent immunostimulatory effects for the treatment of infections, tumors, and immunological diseases, as well as for use as vaccine adjuvants, with the unique advantage of synergistically enhancing immune responses through simultaneous activation of both receptors.

Description

This invention uses 8-hydroxyquinoline derivatives, like Nitroxoline, as effective inhibitors of cathepsin B to block SARS-CoV-2 entry and replication, offering a well-studied, potent antiviral treatment with potential for developing more effective compounds.

Description

New compounds with novel monocyclic fragments and an aminopiperidine naphthyridine moiety show strong antibacterial activity, offering a promising solution to treat infections caused by antibiotic-resistant bacteria.

Description

Quinolin-2-yl nitrones, targeting butyrylcholinesterase and monoamine oxidase B, offer a novel approach for treating Alzheimer's and Parkinson's diseases, with potential for better efficacy and fewer side effects compared to current therapies.

Description

The standard treatment for periodontitis and the associated excessive inflammation is the removal of tartar and biofilm with additional therapies (e.g. antibiotics) and, if necessary, surgery.

Description

A method using monolithic HPLC columns efficiently isolates high-purity osteopontin and glycomacropeptide from whey, reducing environmental impact and providing valuable proteins for functional and medical foods.

Description

The invention introduces enteric-coated lactoferrin particles in capsule form to prevent food poisoning during travel, ensuring safe delivery to the intestines where lactoferrin selectively inhibits harmful bacteria. This user-friendly supplement promotes intestinal health, offers high efficiency and extended shelf life, and targets travelers to regions with higher digestive risks.

Description

We have developed a method for identifying a compound or a composition of compounds that have either anti-bacterial and/or anti-biofilm activities against a bacterium of interest.