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LADME system: mechanisms, kinetics, methods, physico-chemical, technologic and biologic parameters, biopharmaceutical classification system, in vitro-in vivo correlation. Pharmacokinetics, pharmacokinetic-pharmacodynamic relation. Compartmental pharmacokinetics: models, structure, parameters; single/multiple dose pharmacokinetics; one-/two-compartment models; different routes of application, pharmacokinetic analysis of plasma concentration profile and urine cumulative amount profile. Bioavailability and bioequivalence.
Clinical outcomes. Pharmaceutical Care, Pharmacist cognitive services. Guidelines for the use of drugs in selected diseases. Pharmacotherapy of cardiovascular diseases, asthma and chronic obstructive pulmonary disease, psychosis, depression, infections, diabetes, pain. Risks in drug treatment during pregnancy and lactation. Treatment of special populations (children, elderly). Clinical pharmacokinetics and therapeutic drug monitoring. Drug interactions and adverse drug reactions.
Legislation in the area of nutritional supplements. Definitions of basic terms: nutraceuticals, functional food, diet food. Recommended daily intake of nutrients. Vitamins. Vitaminoids. Minerals. Amino acids. Lipids. Carbohydrates. Prebiotics and probiotics. Antioxidants. Bee products. Enzymes. Phytoestrogens.
Pharmacoepidemiology, pharmacovigilance, evidence based medicine, evidence based pharmacy practice, research of structure, proceses and health outcomes, problems connected with drug use, qualitative methods of research: questionnaire, interview, opinion poll, focus groups.